Asthma Risk from Pesticides on Farms

Asthma Risk from Pesticides on Farms



January 2008  - New 
research on farm women has shown that contact with some commonly used 
pesticides may increase their risk of allergic asthma. 
"Farm women are an understudied occupational group," said Jane Hoppin, 
Sc.D., of the National Institute of Environmental Health Sciences and lead 
author of the study. "More than half the women in our study applied 
pesticides, but there is very little known about the risks." 
The study was published in the first issue for January of the "American 
Journal of Respiratory and Critical Care Medicine," published by the 
American Thoracic Society. 
The researchers assessed pesticide and other occupational exposures as 
risk factors for adult-onset asthma in more than 25,000 farmwomen in North 
Carolina and Iowa.
 
They used self-reports of doctor-diagnosed adult asthma, and divided the 
women into groups of allergic or non-allergic asthma based on a history of 
eczema and/or hay fever. 
They found an average increase of 50 percent in the prevalence of allergic 
asthma in all farm women who applied or mixed pesticides. 
Although the association with pesticides was higher among women who grew 
up on farms, these women still had a lower overall risk of having allergic 
asthma compared to than those who did not grow up on farms, due to a 
protective effect that remains poorly understood. 
"Growing up on a farm is such a huge protective effect it's pretty hard to 
overwhelm it," said Dr. Hoppin. "[But] about 40 percent of women who work 
on farms don't report spending their childhoods there. It is likely that 
the association with pesticides is masked in the general population due to 
a higher baseline rate of asthma." 
Dr. Hoppin also found that most pesticides were associated only with 
allergic asthma, even though non-allergic asthma is generally more common 
in adults. 
Some legal but rarely used compounds, such as parathion, were associated 
with almost a three-fold increase in allergic asthma. But even some 
commonly used pesticides were associated with a marked increase in 
allergic asthma prevalence. 
Malathion, for example, a widely used insecticide, was associated with a 
60 percent increased prevalence of allergic asthma. 
Of all the compounds examined, only permethrin, a commonly used 
insecticide that is used in consumer items such as insect-resistant 
clothing to anti-malaria bed-nets, was associated with both allergic and 
non-allergic asthma. 
This is the first study to examine pesticides and asthma in farm women, 
and it points the way for future research to clarify the relationship. 
"There is a difference in asthma prevalence between women who did and did 
not use pesticides but whether it is causal or not remains to be seen," 
said Dr. Hoppin. 
Dr. Hoppin and her colleagues are planning a large scale study that will 
better evaluate the links between pesticide exposures and asthma. "We want 
to characterize the clinical aspects of this disease, as well as lifetime 
exposures to agents that may either protect against asthma or increase 
risk," said Dr. Hoppin. "We hope to start the study in 2008." 

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